Experimental implant-related osteomyelitis treated by antibiotic-calcium hydroxyapatite ceramic composites
- 1 January 1993
- journal article
- Published by British Editorial Society of Bone & Joint Surgery in The Journal of Bone and Joint Surgery. British volume
- Vol. 75-B (1) , 111-114
- https://doi.org/10.1302/0301-620x.75b1.8380599
Abstract
The efficacy of locally implanted antibiotic-calcium hydroxyapatite ceramic composites was investigated for the treatment of experimentally produced, implant-related osteomyelitis in rats. High concentrations of antibiotics were detected at the site of infection and bacteria were eradicated without removal of the metal implants. Parenteral antibiotics and surgical debridement, alone or in combination with antibiotic-impregnated acrylic bone cement, all failed to eradicate the infections.Keywords
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