GENETIC CONTROL OF SERUM IMMUNOGLOBULIN G LEVELS IN THE CHICKEN

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Abstract
Serum IgG (7S) levels differed significantly for chickens from 10 different inbred lines. Within lines, differences between B blood groups were statistically significant. The genetic control of serum IgG was further examined using birds from B. complex haplotypes marked at the B locus and the Ir-GAT locus. Birds from each of 5 subgroup haplotypes (B1B1 Ir-GAT-Lo and -Hi, B19B19 Ir-GAT-Lo and -Hi, and B2B2 Ir-GAT intermediate) were tested for levels of serum IgG at 3, 6, 9 and 21 wk of age. The rate and level of IgG reached in the serum was > 2-fold greater in the GAT-Hi birds than in the GAT-Lo. The Ir [immune response] region of the B complex exerts some control over the ontogenesis of IgG, though most of the genetic variation seems not to be B complex associated.