Synthesis and Biological Evaluation of 3-Chloro-4-(D-Ribofuranosyl)-Pyridine and 3-(D-Ribofuranosyl)-2- Pyridone

1 January 1987

journal article
research article
Published by Taylor & Francis in Nucleosides and Nucleotides

Vol. 6 (1-2) , 245-248
https://doi.org/10.1080/07328318708056197

Abstract

Condensation of 2-fluoro-3-lithio pyridine and 3-chloro-4-lithio pyridine with 2,4:3,5-di-O-benzylidene-alde-hydo-D-ribose gives the corresponding D-allo- and D-altro-addition products. These were converted into the corresponding mesylates and cyclized to the ribofuranosyl nucleosides with an overall yield of 60–70 %. Both nucleosides did not show any inhibitory effect on L-₁₂₁₀-cells.

Keywords

This publication has 3 references indexed in Scilit:

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