Effects of 2-mercapto-1-(beta-4-pyridethyl)-benzimidazole (MPB) on Ehrlich cell nucleoli: stereological analysis
- 1 January 1985
- journal article
- research article
- Published by Wiley in Biology of the Cell
- Vol. 53 (2) , 111-115
- https://doi.org/10.1111/j.1768-322x.1985.tb00360.x
Abstract
The effects of MPB [a-mercapto-1-(.beta.-4-pyridethyl)-benzimidazole], a strong inhibitor of RNA synthesis were analyzed at the ultrastructural level by means of stereological methods. After treatment, an increase in the nucleolar volume is observed. This enlargement is due to vacuolization of the nucleoli. The relative volumes of the nucleolar components are modified in various directions: the volume of the granular component decreases whereas the fibrillar centers increase in size. These results are discussed in terms of relations between morphology and function of the nucleolus.This publication has 7 references indexed in Scilit:
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