Sex hormone receptors in mammary tumours of GR mice

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Abstract
Studies of the growth behavior and hormone receptor contents of GR mouse mammary tumors suggest that the hormone responsive tumors are mixed populations of hormone dependent and autonomous cells. The hormone dependent moiety of these tumors contains high levels of progesterone and estrogen receptors. The autonomous moiety has a low but probably significant estrogen receptor level, and is practically devoid of progesterone receptors. Androgen receptor levels in both moieties are low. Endocrine ablation prevents growth of the hormone dependent moiety of the tumors, but not the autonomous moiety.