Allergic purpura induced by exposure to p-dichlorobenzene. Confirmation by indirect basophil degranulation test

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Abstract
Allergic (anaphylactoid) purpura was induced by p-dichlorobenzene, an apparently innocuous and widely used moth repellent. Acute glomerulonephritis presented as a complication of the allergic purpura. The offending agent was p-dichlorobenzene, proved by the indirect basophil degranulation test. Serum antibodies for p-dichlorobenzene were still demonstrable in this patient 5 months after the initial exposure. The basophil degranulation test has obvious advantages over clinical methods in establishing a suspected drug or chemical as the offending agent in a clinical reaction. The values of indirect basophil degranulation test are the accuracy of identification of offending chemical or drug achieved as a laboratory procedure, without subjecting a patient to the hazards and jeopardy of a cautious clinical trial or reexposure to the offending agent.

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