IMPROVEMENTS ON THE ARTIFICIAL KIDNEY: AN EXPERIMENTAL STUDY OF ITS APPLICATION TO DOGS BILATERALLY NEPHRECTOMIZED OR OTHERWISE DEPRIVED OF RENAL FUNCTION

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Abstract
The artificial kidney has been applied successfully to dogs deprived of renal excretory function by bilateral nephrectomy or other procedures. A study of the artificial kidney as used by previous workers revealed numerous sources of difficulty. Details are given for the correction of these defects including methods for the chemical treatment of the dialyzing membrane, the composition of the dialyzing fluid, the prevention of overload of the circulation, and other fundamental considerations which previous investigators have overlooked. By attention to these details it has been possible to maintain dogs deprived of renal excretory function for a period of a month, after which they were killed for histologic study.