β‐MICROGLOBULIN SERUM LEVELS IN INFECTIOUS MONONUCLEOSIS IN CHILDHOOD

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Abstract
A material of fifteen children aged 10 months to 15 years with infectious mononucleosis (IM) was investigated. The diagnosis was established by demonstration of Epstein-Barr virus (EBV) specific lgM antibodies. The serum concentrations of β-microglobulin (β2-m) were significantly increased (p2-m decreased towards normal range within 3 weeks- 3 months. During the same period, IgM antibodies to EBV decreased to unmeasurable levels, and the IgG titers were almost constant. Serum β2-m may be a parameter of value in the diagnosis of infectious mononucleosis in childhood, replacing tests for heterophile antibodies (Emni test and Paul-Bunnell test) which are often negative in children suffering from a primary EBV infection, or it may be used for assessment of disease activity.

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