Talin anchors and nucleates actin filaments at lipid membranes A direct demonstration
- 14 December 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 314 (2) , 203-205
- https://doi.org/10.1016/0014-5793(92)80975-m
Abstract
Platelet talin nucleates actin assembly as we show here directly by using rhodamine-phalloidin labelling of actin filaments. Nucleation by talin still occurs after reconstitution into liposomal bilayers. This is also demonstrated directly after protein-lipid double labelling and light microscopic imaging. Talin, thus, is the first actin binding protein for which anchoring and nucleation of actin filament growth at lipid interfaces have been visualized.Keywords
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