Mechanisms of Endothelial Differentiation in Embryonic Vasculogenesis
- 1 November 2005
- journal article
- review article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 25 (11) , 2246-2254
- https://doi.org/10.1161/01.atv.0000183609.55154.44
Abstract
The formation of new blood vessels in the adult organism not only contributes to the progression of diseases such as cancer and diabetic retinopathy but also can be promoted in therapeutic approaches to various ischemic pathologies. Because many of the signals important to blood vessel development during embryogenesis are recapitulated during adult blood vessel formation, much work has been performed to better-understand the molecular control of endothelial differentiation in the developing embryo. In this review, we describe the current understanding of where endothelial differentiation from pluripotent progenitor cells occurs during development, how this process is controlled at the molecular level, and what model systems can be used to investigate the earliest steps of blood vessel formation.Keywords
This publication has 104 references indexed in Scilit:
- Sphingosine-1-phosphate Signaling Promotes Critical Migratory Events in VasculogenesisJournal of Biological Chemistry, 2004
- Coronary Vessel DevelopmentArteriosclerosis, Thrombosis, and Vascular Biology, 2003
- Converging roads: evidence for an adult hemangioblastExperimental Hematology, 2003
- The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragilityThe Journal of cell biology, 2003
- PLEXIN‐D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesisDevelopmental Dynamics, 2002
- Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1Biochemical and Biophysical Research Communications, 2001
- Heterozygous embryonic lethality induced by targeted inactivation of the VEGF geneNature, 1996
- Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleNature, 1996
- Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceNature, 1995
- Preliminary note on the differentiation of angioblasts and the method by which they produce blood‐vessels, blood‐plasma and red blood‐cells as seen in the living chickThe Anatomical Record, 1917