Circumdatin G, a New Alkaloid from the Fungus Aspergillus ochraceus
- 21 December 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 64 (1) , 125-126
- https://doi.org/10.1021/np000381u
Abstract
The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication. Bioassay-guided fractionation led to the isolation of the known compound mellein as the active component of the extract. Also isolated were circumdatin F and a new alkaloid, circumdatin G. The structure of circumdatin G was determined by spectroscopic analysis.Keywords
This publication has 5 references indexed in Scilit:
- NS3. A protease as a target for interfering with hepatitis C virus replicationDrug News & Perspectives, 2000
- Circumdatins D, E, and F: Further Fungal Benzodiazepine Analogues from Aspergillus ochraceusJournal of Natural Products, 1999
- Circumdatin A, B, and C: Three New Benzodiazepine Alkaloids Isolated from a Culture of the Fungus Aspergillus ochraceusThe Journal of Organic Chemistry, 1999
- Three New Metabolites from Marine-Derived Fungi of the Genera Coniothyrium and MicrosphaeropsisJournal of Natural Products, 1998
- Dihydroisocoumarins from fungi: Isolation, structure elucidation, circular dichroism and biological activityPhytochemistry, 1997