Dermal pharmacokinetics of the insecticide furathiocarb in rats

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Abstract
The pharmacokinetics of furathiocarb were studied in vivo in male Sprague–Dawley rats following dermal treatment. HPLC and post‐column derivatization were used for the analysis of furathiocarb and its metabolites (carbofuran, 3‐hydroxycarbofuran and 3‐ketocarbofuran). Carbofuran and 3‐hydroxycarbofuran were detected in plasma and urine rather than furathiocarb. 3‐Ketocarbofuran, another potential metabolite, was not observed in any sample. The concentration of carbofuran was higher than that of 3‐hydroxycarbofuran in plasma, but the reverse was the case in urine. The corresponding area under the plasma concentration–time curve, Tmax, and Cmax values of carbofuran and 3‐hydroxycarbofuran for 1500 mg kg−1 doses were 2.4–8.0 mg equiv h ml−1, 12 h and 0.1–0.4 mg equiv ml−1, respectively. T1/2 was calculated only for 3‐hydroxycarbofuran (28 h). Two metabolites were excreted in a dose‐dependent manner without saturation. © 2001 Society of Chemical Industry