Identification of Inhibitors for a Virally Encoded Protein Kinase by 2 Different Screening Systems: In Vitro Kinase Assay and In-Cell Activity Assay
Open Access
- 1 February 2005
- journal article
- Published by Elsevier in SLAS Discovery
- Vol. 10 (1) , 36-45
- https://doi.org/10.1177/1087057104270269
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- Novel Chemical Class of pUL97 Protein Kinase-Specific Inhibitors with Strong Anticytomegaloviral ActivityAntimicrobial Agents and Chemotherapy, 2004
- The Human Cytomegalovirus UL97 Protein Kinase, an Antiviral Drug Target, Is Required at the Stage of Nuclear EgressJournal of Virology, 2003
- Relationship between Autophosphorylation and Phosphorylation of Exogenous Substrates by the Human Cytomegalovirus UL97 Protein KinaseJournal of Virology, 2002
- Direct targeting of human cytomegalovirus protein kinase pUL97 by kinase inhibitors is a novel principle for antiviral therapyJournal of General Virology, 2002
- Inhibitors of human cytomegalovirus replication drastically reduce the activity of the viral protein kinase pUL97Journal of General Virology, 2001
- Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidationProceedings of the National Academy of Sciences, 2001
- Functional regions of the human cytomegalovirus protein pUL97 involved in nuclear localization and phosphorylation of ganciclovir and pUL97 itself.Journal of General Virology, 1998
- The Myristoylated Alanine‐Rich C‐Kinase Substrate (MARCKS) is Sequentially Phosphorylated by Conventional, Novel and Atypical Isotypes of Protein Kinase CEuropean Journal of Biochemistry, 1995
- Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovirNature, 1992
- Symptomatic congenital cytomegalovirus infectionThe Pediatric Infectious Disease Journal, 1992