RECOVERY OF 2'-DEOXYCOFORMYCIN-INHIBITED ADENOSINE-DEAMINASE OF MOUSE ERYTHROCYTES AND LEUKEMIA-L1210 INVIVO

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (4) , 1425-1427
Abstract
The antibiotic 2''-deoxycoformycin, a potent inhibitor of adenosine deaminase, has potential as a chemotherapeutic agent. Injection of 2''-deoxycoformycin i.v. (0.2 mg/kg) to mice bearing ascites L1210 leukemia cells completely inhibits adenosine deaminase in erythrocytes and L1210 cells. The recovery of the enzymic activity is markedly different in the 2 tissues. The recovery is very slow in erythrocytes (13% in 48 h), whereas 80% recovery occurs during the same time interval in L1210 cells. This marked difference in the recovery of the enzyme in different tissues may play a role in the pharmacological and chemotherapeutic behavior of this drug.