Tandem Transacylation/Debenzylation of β-Lactones Mediated by FeCl3 Leading to γ- and δ-Lactones: Application to the Synthesis of (-)-Grandinolide
- 1 March 1996
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1996 (03) , 278-280
- https://doi.org/10.1055/s-1996-5391
Abstract
The one step conversion of β-lactones bearing a pendant benzyloxy group to γ- and δ-lactones via a transacylation/debenzylation process is effected using FeCl3. This procedure in conjunction with a previously reported diastereoselective [2+2] cycloaddition has been applied to an asymmetric synthesis of (-)-grandinolide.Keywords
This publication has 0 references indexed in Scilit: