sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins
Open Access
- 1 December 1997
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 11 (23) , 3182-3193
- https://doi.org/10.1101/gad.11.23.3182
Abstract
Mutations that influence lin-12 activity inCaenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a member of the CDC4 family of proteins and has a potential human ortholog. Coimmunoprecipitation data indicate that C. elegansSEL-10 complexes with LIN-12 and with murine Notch4. We propose that SEL-10 promotes the ubiquitin-mediated turnover of LIN-12/Notch proteins, and discuss potential roles for the regulation of lin-12/Notch activity bysel-10 in cell fate decisions and tumorigenesis.Keywords
This publication has 64 references indexed in Scilit:
- C. elegans: des neurones et des gènesmédecine/sciences, 2003
- Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decisionCell, 1994
- The ancient regulatory-protein family of WD-repeat proteinsNature, 1994
- TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasmsPublished by Elsevier ,1991
- Basic Local Alignment Search ToolJournal of Molecular Biology, 1990
- Basic local alignment search toolJournal of Molecular Biology, 1990
- A novel genetic system to detect protein–protein interactionsNature, 1989
- Cell autonomy of lin-12 function in a cell fate decision in C. elegansCell, 1989
- The lin-12 locus specifies cell fates in caenorhabditis elegansCell, 1983
- Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegansDevelopmental Biology, 1981