Trials of Ganglioside Therapy for Amyotrophic Lateral Sclerosis and Diabetic Neuropathy
- 1 January 1984
- book chapter
- Published by Springer Nature
- Vol. 174, 575-579
- https://doi.org/10.1007/978-1-4684-1200-0_48
Abstract
In a number of experimental situations exogenously administered gangliosides have been demonstrated to speed recovery from axonotmesis. First demonstrated for the pre-and postganglionic sympathetic fibers of the cat nictitating membrane,1 it has now been demonstrated also for the rat sciatic nerve2 and rat tail nerve.3 The mechanism of action seems to be stimulation of the sprouting process.3,4 Hence, gangliosides would be expected to be beneficial in conditions such as traumatic nerve injury and mononeuritis from focal nerve infarction. Therapy would reduce the time of disability. Additionally, if regrowth of nerve is sometimes limited by fibrosis in the region of injury, then rapid growth out of this region would improve the quality of recovery.Keywords
This publication has 6 references indexed in Scilit:
- Electromyographic study of diabetic and alcoholic polyneuropathic patients treated with gangliosidesMuscle & Nerve, 1982
- Ganglioside treatment of neuropathy in diabetic miceMuscle & Nerve, 1982
- Acceleration of nerve regeneration by gangliosides estimated by the somatosensory evoked potentials (SEP)Cellular and Molecular Life Sciences, 1981
- Comparison of clinical couse and sequential electrophysiological tests in diabetics with symptomatic polyneuropathy and its implications for clinical trialsDiabetes, 1981
- Motor nerve sprouting induced by ganglioside treatment. Possible implications for gangliosides on neuronal growthBrain Research, 1980
- Effects of Cerebral Gangliosides in the Alcoholic PolyneuropathiesEuropean Neurology, 1980