A SAFE BLOOD TRANSFUSION PROCEDURE FOR IMMUNIZATION AGAINST MAJOR HISTOCOMPATIBILITY COMPLEX DETERMINANTS IN MAN

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Abstract
A standardized procedure is proposed for deliberate immunizations against human major histocompatibility complex determinants. The data presented demonstrate its effectiveness and, by using a number of necessary precautions, this procedure was very safe. The following points are especially important: exclusive utilization of regular blood donors as immunizers; use of whole blood as an immunizing agent; and use of small immunizing stimuli rather than large transfusions. This procedure can be recommended for the production of monospecific anti-HLA antisera and it may be useful if and when a deliberate transfusion policy for prospective kidney recipients is adopted.

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