EFFECT OF THEOPHYLLINE ON THE RESPONSES OF THE GUINEA-PIG URINARY-BLADDER TO NERVE-STIMULATION, ADENOSINE 5' TRIPHOSPHATE AND HISTAMINE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 236  (1) , 125-130
Abstract
The effects of theophylline (10-5 M, 10-4 M and 10-3 M) on the contractile responses of the guinea-pig urinary bladder to nerve stimulation, ATP and histamine were investigated. Contractile responses were unaffected by 10-5 M and 10-4 M theophylline but were significantly reduced by 10-3 theophylline. Since responses to histamine were reduced to a similar extent as responses to ATP, theophylline may not be a specific antagonist of ATP in this tissue and ATP receptors in the bladder may differ from those in other smooth muscle preparations.