Changes in Serum and Hepatic Cholesterol in Lead-Induced Liver Hyperplasia
Open Access
- 1 February 1984
- journal article
- research article
- Published by SAGE Publications in Toxicologic Pathology
- Vol. 12 (2) , 162-167
- https://doi.org/10.1177/019262338401200208
Abstract
Lead nitrate when injected intravenously as a single dose to male Wistar rats causes a strong hepatic proliferative response followed by reabsorption of excess tissue within 10-14 days. The rate of cell proliferation in this hyperplastic model was positively correlated with hepatic de novo synthesis of cholesterol, stimulation of the hexose monophosphate shunt pathway of glucose metabolism and with alterations in serum lipoproteins.Keywords
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