Serotonin as a Differentiation Signal in Early Neurogenesis
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Developmental Neuroscience
- Vol. 1 (1) , 15-30
- https://doi.org/10.1159/000112549
Abstract
The hypothesis that serotonin (5-HT) influences the onset of differentiation (cessation of division) of prospective 5-HT target neurons during embryogenesis was tested by administering the 5-HT depleting drug p-chlorophenylalanine (pCPA) to pregnant rats and dating the time of last cell division for fetal neurons using long survival 3H-thymidine autoradiography. PCPA specifically retarded the onset of neuronal differentiation in brain regions known to contain 5-HT terminals or to have a high 5-HT content in the adult (5-HT target cells). The stress of daily vehicle injections accelerated differentiation onset in these regions, possibly due to stimulation of 5-HT synthesis by glucocorticoids. These data support the model of 5-HT as a humoral signal for the differentiation of cells later recognized by 5-HT neurons as appropriate targets for synaptogenesis.This publication has 11 references indexed in Scilit:
- Axonal transport in serotonin neurons of the midbrain rapheBrain Research, 1976
- Neurotransmitter Regulation of Adenosine 3′,5′-Monophosphate in Clonal Nerve, Glia, and Muscle Cell LinesScience, 1976
- CATECHOLAMINE-MEDIATED ELEVATION OF CYCLIC-GMP IN RAT C-6 GLIOMA CELL LINE1976
- Serotonin axons in the supra- and subependymal plexuses and in the leptomeninges; Their roles in local alterations of cerebrospinal fluid and vasomotor activityBrain Research, 1976
- The development of hippocampal and dorsolateral pallial regions of the cerebral hemisphere in fetal rabbits. III. Twenty-nine millimeter stage, marginal laminaJournal of Comparative Neurology, 1967
- The development of hippocampal and dorsolateral pallial regions of the cerebral hemisphere in fetal rabbits. II. Twenty millimeter stage, neuroblast morphologyJournal of Comparative Neurology, 1967
- Response of the Infantile Rat to StressEndocrinology, 1966
- Cleft Palate in the Mouse: A Teratogenic Index of Glucocorticoid PotencyScience, 1965
- The rôle of neurohumours in early embryogenesis. : I. Serotonin content of developing embryos of sea urchin and loachDevelopment, 1964
- Multiple Range and Multiple F TestsPublished by JSTOR ,1955