The Effects of Vitamin Deficiency on Some Physiological Factors of Importance in Resistance to Infection III. Vitamin B12 and Folic Acid Deficiencies

Abstract
Male white rats were maintained on a well-defined diet deficient in vitamin B12 and folic acid and various physiological factors of resistance to infection were studied. Adequate inanition- and ad libitum-control animals were included in the investigation. The following physiological factors were studied: (1) cellular composition of the peripheral blood; (2) complement activity; (3) cellular migration in inflammation; (4) cellular composition of the exudate in inflammation; (5) “leukotaxine” activity; and (6) cellular composition of bone marrow. The following observations were made from these studies:

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