Oral Vaccination of Mice with Adenoviral Vectors Is Not Impaired by Preexisting Immunity to the Vaccine Carrier
Open Access
- 15 October 2003
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (20) , 10780-10789
- https://doi.org/10.1128/jvi.77.20.10780-10789.2003
Abstract
E1 deletion adenoviral vectors of the human serotype 5 (AdHu5) and the chimpanzee serotype 68 (AdC68) expressing the rabies virus glycoprotein (rab.gp) were tested for induction of transgene product-specific antibodies upon intranasal or oral immunization of newborn mice. Both vectors induced antibodies to rabies virus that could be detected in serum and mucosal secretions. Serum rabies virus-neutralizing antibody titers sufficed to protect neonatally vaccinated mice against a subsequent challenge with rabies virus. The efficacy of the AdHu5rab.gp vector given orally to newborn mice born to AdHu5-immune dams was not impaired by maternally transferred antibodies to the vaccine carrier.Keywords
This publication has 35 references indexed in Scilit:
- Novel, Chimpanzee Serotype 68-Based Adenoviral Vaccine Carrier for Induction of Antibodies to a Transgene ProductJournal of Virology, 2002
- Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunityNature, 2002
- Replication-Defective Vector Based on a Chimpanzee AdenovirusJournal of Virology, 2001
- Protection against Tetanus by Needle-Free Inoculation of Adenovirus-Vectored Nasal and Epicutaneous VaccinesJournal of Virology, 2001
- In vivo transfection and/or cross-priming of dendritic cells following DNA and adenoviral immunizations for immunotherapy of cancer—changes in peripheral mononuclear subsets and intracellular IL-4 and IFN-γ lymphokine profileCritical Reviews in Oncology/Hematology, 2001
- Ensuring vaccine safety in immunization programmes — a WHO perspectiveVaccine, 2001
- Induction of mucosal immunity with a replication-defective adenoviral recombinantVaccine, 1999
- A Replication-Defective Human Adenovirus Recombinant Serves as a Highly Efficacious Vaccine CarrierVirology, 1996
- Vaccination with a Plasmid Vector Carrying the Rabies Virus Glycoprotein Gene Induces Protective Immunity against Rabies VirusVirology, 1994
- Oral poliovirus vaccine. History of its development and prospects for eradication of poliomyelitisPublished by American Medical Association (AMA) ,1965