Syntheses of ornithine decarboxylase inhibitors: D- and DL-.ALPHA.-hydrazinoornithine.

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Abstract
The absolute configuration of optically active .alpha.-hydrazinoornithine, which was prepared by the reaction of hydrazine with the .alpha.-bromo acid derived from L-ornithine, was the D-configuration. Racemic .alpha.-hydrazinoornithine was 1st prepared by 2 different methods. Ornithine decarboxylase is important in decarboxylation of L-ornithine which is important in polyamine biosynthesis. Polyamines may participate in the biosynthesis of protein and RNA and may be associated with cell growth and rapidly growing tumors.

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