Solubilization or Emulsification of Dietary Monoacylglycerols by Bile Salts

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Abstract
To clarify the roles of bile salts in fat absorption through the unstirred water layer covering epithelial cells, the dispersion of monoolein and beef tallow hydrogenated monoacylglycerol (monoglyceride) was investigated with respect to their states in aqueous solutions of two bile salts, sodium taurochenodeoxycholate and sodium tauroursodeoxycholate. After mixing and incubating solutions of dietary monoacylglycerols and bile salts, each was centrifuged and filtrated using a 0. 22μm membrane filter. The concentration of dissolved monoacylglycerol was then measured. The concentration of unsaturated monoacylglycerol considerably exceeded that of the saturated monoacylglycerol. In bile salt solution, the former dispersed to form an emulsion while the latter solubilized to form mixed micelles. In the case of either monoacylglycerol, the dispersion ability of chenodeoxycholate solution was much stronger than that of ursodeoxycholate solution.

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