AMINO NITROGEN IN LIVER AND MUSCLE OF RATS IN SHOCK AFTER HEMORRHAGE

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Abstract
In rats in shock after hemorrhage, the concn. of free amino nitrogen rises in the liver and in muscle (gastrocnemius). This increase is not due to the inclusion of plasma of high amino nitrogen content but is mainly in the intracellular compartment. These data confirm previous indications of an increase in the rate of release of amino acids from muscle, and show that in the liver also the normal balance between formation and breakdown of cellular protein is disturbed. These 2 factors, as well as a relative failure in the catabolism of amino acids, then contribute to the increase in plasma amino N which occurs in hemorrhagic shock.

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