THE MAINTENANCE OF MUSCLE GLYCOGEN IN FASTED HYPOPHYSECTOMIZED-ADRENALECTOMIZED RATS1

Abstract
A crude alkaline extract of the ant. pituitary when given only during the fasting period maintained normal muscle glycogen levels of 24-hr. fasted, hypophysectomized, and hypophysectomized-adrenalectomized rats. Pure ACTH was without effect. The presence of adrenal cortical hormones was not necessary for the "myoglycostatic" effect, as complete maintenance of muscle glycogen stores could be obtained in animals proven to have adrenal cortical insufficiency and maintained for long periods of time on salt prior to hypophysectomy.

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