Acute Hemolytic Anemia, Cryoglobulinemia and Cold Agglutination

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Abstract
THE term cryoglobulinemia, from the Greek κρν́ος meaning cold, was coined by Lerner and Watson1 to describe abnormal globulins that have the physical characteristics of precipitating on cooling and redissolving on subsequent warming. These authors reviewed the fourteen prior reports on this subject.2 In addition to cases associated with subacute bacterial endocarditis3 and other diseases that occasionally exhibit small amounts of cryoglobulins,2 , 4 20 cases of high-grade cryoglobulinemia have since been reported.Rørvik5 has recently described a patient with severe Raynaud syndrome who had an extremely high cold-agglutinin titer and cryoglobulinemia, and a mild chronic hemolytic anemia. Previously, Craig et al. . . .