Effects of Estrogen Replacement Therapy on Cerebral Perfusion and Cognition among Postmenopausal Women

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Abstract
Previous investigations concerned with effects of estrogen replacement therapy (ERT) in older women have focused primarily on morbidity and mortality as measures of outcome. A retrospective study is reported here that investigated the effects of ERT in older women with and without cerebrovascular disease on measures of cerebral perfusion and cognition. Results indicate that ERT was significantly correlated with higher cognitive test performance among women with a history of cerebrovascular disease. There was also a trend for increased cerebral perfusion among women with cerebrovascular disease receiving ERT. Results are consonant with previous reports that estrogen exerts ‘protective effects’ among patients with cerebrovascular disease and suggest that estrogen replacement may stabilize the deleterious effects of progressive cerebrovascular disease by helping to sustain cerebral perfusion and cognition among women with a history of cerebrovascular disease.

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