THE STRUCTURAL BASIS FOR GENETIC VARIATIONS OF NORMAL HUMAN γ-GLOBULINS

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Abstract
3.55 fragments prepared from 7S gamma globulins from sera of a variety of Gm types were assayed for their Gml(a) and (b) and InV (a) and (b) activities. These two activities, which are controlled by two distinct genetic loci, were found on different parts of the gamma globulin molecule. InV activity was always recivered with fragments A and C, while Gml activity was always associated with fragment B. InV activity, but not Gml activity, was also associated with 19S gamma globulins, gamma-1A globulins, and the majority of Group B Bence Jones proteins. All of these proteins cross-react with fragments A and C of 7S gamma-globulins. The finding of two activities which are under separate genetic control on different parts of the gamma-globulin molecule suggests that these genes may control individual chains of the gamma-globulin molecules.