Comparison of Leukocyte Changes Produced by Pyrogens and by Anaphylaxis in the Guinea Pig.

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Abstract
Changes in circulating leukocytes which occur after anaphylaxis were compared with those after pyrogen injn. in guinea pigs. Following both of these reactions there is immediate leukopenia followed by polymorphonuclear leukocytosis. The initial leukopenia followed by leukocytosis which occurs after re-injection of an antigen in a sensitized animal is separate and distinct from the hematologic changes after pyrogen injn. The 2 responses are distinguishable by direct eosinophil counts which revealed uniform rises with anaphylaxis and uniform falls with the pyrogenic reaction. The mechanism of these hematologic changes was not touched upon in this study. It was concluded that the leukocyte changes after anaphylaxis are not due to pyrogen contamination.

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