2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase and 5′‐Nucleotidase in the Central Nervous System of a Myelin‐Deficient Rat Mutant
- 1 June 1984
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 42 (6) , 1767-1770
- https://doi.org/10.1111/j.1471-4159.1984.tb12770.x
Abstract
2',3'-Cyclic nucleotide 3'-phosphodiesterase activity was examined in brains and spinal cords of normal and myelin-deficient Wistar rats. While the activity in normal brains increased from 0.2 mumol/min/mg protein (units) at 6-10 days to 3.5 units at 25 days of postnatal age, the activity in the myelin-deficient rat remained at 0.2-0.3 units over the same period. In spinal cord, the normal activities were 5.7 and 10.9 units at 12 and 20 days, respectively, whereas they declined in the myelin-deficient rat from 1.06 to 0.79 units for the same age points. 5'-Nucleotidase activities in brain and spinal cord were normal in the myelin deficient rat at both ages.Keywords
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