Serotonin and ?-thromboglobulin release reaction from platelet as triggered by interaction with polypeptide derivatives

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Abstract
The effect of wettability of 14 polypeptide derivatives upon adhesion and activation of platelets was investigated with reference to release reactions from adhered platelets, using radioisotope labeling and radio-immunoassay method. The serotonin release was more significant from platelets adhered to polymer materials to which a large number of platelets are adhered. However, no clear relationship was found between adhesion of platelets and β-thromboglobulin release from adhered platelets. Therefore, stimuli inducing serotonin release and β-thromboglobulin release were considered to be from different origins. The trend in β-thromboglobulin release was well correlated with the extent of morphological change of adhered platelets as observed by scanning electron microscope. It was suggested that the determination of released β-thromboglobulin in association with the measurement of platelet adhesion could be useful for evaluation of blood compatibility of materials.