Effect of combined misonidazole and d(50)-Be neutrons on a human melanoma transplanted into nude mice.

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Abstract
The effect of 2 different doses (0.1 and 1 mg/g) of misonidazole on the radiosensitivity of human Na 11 melanoma cells transplanted into athymic nude mice is reported. The mice were irradiated with 50 MeV neutrons. The end point was the in vitro colony-forming assay. Repair of potentially lethal damage following neutron irradiation was comparable to that observed after .gamma. irradiation. This repair was no longer detectable when 1 mg/g of misonidazole was used. When the 1 mg/g dose was used, the observed enhancement ratios after neutron irradiation were 1.52 for immediate plating and 1.87 for delayed plating. No toxic effect of the drug itself was detected.