EFFECTIVE CONTROL OF CISPLATIN-INDUCED NAUSEA USING HIGH-DOSE STEROIDS AND DROPERIDOL

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 66  (2) , 243-245
Abstract
Seventy-three consecutive [cancer] patients receiving cisplatin-containing chemotherapy regimens were treated with an initial dose of chlorpromazine (24 mg i.m.), droperidol (1 mg i.v., then 1 mg s.c. every 4 h) and methylprednisolone (250 mg every 4 h for 4 dosees). Twenty patients received a combination chmotherapy protocol that includes cisplatin at a dose of 40 mg/m2 i.v. (group 1); 53 patients received a protocol that included cisplatin at a dose of 120 mg/m2 i.v. (group 2). The median age of all the patients was 58 yr. Seventy-five percent of the patients in group 1 and 45% of those in group 2 had no vomiting at all; the remainder had limited and tolerable vomiting. These results in a group of elderly patients compare favorably with trials of other antiemetic programs.