Correlation Between Lymphocyte β2-Adrenoceptor Density and Mean Arterial Blood Pressure

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Abstract
In 41 normotensive volunteers (diastolic pressure, 95 mm Hg). The mean number of β2-adrenoceptors for controls was 774 ± 49 (range, 300–1,500) ICYP binding sites/cell. In borderline hypertension it was significantly higher, with 1,037 ± 22 (range, 950–1,150) sites/cell, and increased further in patients with essential hypertension to 1,424 ± 72 (range, 700–2,700) sites/cell. The KD values for ICYP, however, were nearly the same in all groups (∼50 pM). Calculation of the data of all 95 subjects resulted in a significant positive correlation between β2-adrenoceptor density and mean arterial blood pressure (r = 0.637; p < 0.001). Since the properties of β2-adrenoceptors in human lymphocytes resemble those in other tissues, the hypothesis is presented that the increased density of β2-adrenoceptors may reflect sympathetic hyperactivity in essential hypertension, which might contribute (perhaps via enhanced release of endogenous noradrenaline through stimulation of presynaptic β2-adrenoceptors by adrenaline) to the elevation of blood pressure.