Reduced Clinical Effect of Monofluorophosphate in the Presence of Sodium Lauryl Sulphate

Publisher Website
Google Scholar
Abstract
It was shown that addition of 2% sodium lauryl sulphate to a 3% aqueous solution of sodium monofluorophosphate reduced the caries-inhibiting potential of the monofluorophosphate solution significantly, when this solution was applied topically at fortnightly intervals. It is suggested that this may be due to enzyme inhibition by the lauryl sulphate, denaturing bacterial enzymes in the oral cavity which would otherwise release free fluoride from the monofluorophosphate molecule. Almost all commercial toothpaste with sodium monofluorophosphate contains high amounts of sodium lauryl sulphate. It is suggested that this may impair the clinical effect of these toothpastes.

This publication has 1 reference indexed in Scilit: