Effect of abdominal vagotomy of the pregnant rat on LH and progesterone concentrations and fetal resorption
- 1 May 1978
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 53 (1) , 131-136
- https://doi.org/10.1530/jrf.0.0530131
Abstract
Abdominal vagotomy on day 8 of pregnancy in rats decreased the number of live fetuses at day 16 and increased the number of resorbing fetuses. The activity of .DELTA.5-3.beta.-hydroxysteroid dehydrogenase (3.beta.-HSD) in the corpus luteum and interstitial gland, LH [luteinizing hormone] and progesterone values in plasma and progesterone values in ovarian tissue were all lower in vagotomized rats than in sham-operated controls. Ovarian PG[prostaglandin]F levels were not affected. These effects were probably caused by a direct effect of vagotomy on LH secretion which in turn lowers 3.beta.-HSD activity and progesterone levels in ovarian tissue and plasma, leading to fetal resorption.This publication has 0 references indexed in Scilit: