Antigenicity and Reactogenicity of Influenza A/USSR/77 Virus Vaccine in Children -- A Multicentered Evaluation of Dosage and Safety
- 1 July 1983
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 5 (4) , 758-764
- https://doi.org/10.1093/clinids/5.4.758
Abstract
Clinical trials of monovalent A/USSR/77 (H1N1) and trivalent A/USSR/77 (H1N1), A/Texas/77 (H3N2), and B/Hong Kong/72 inactivated influenza virus vaccines were carried out in 358children and adolescents. Only split-virus vaccines were administered to children younger than 13 years of age. No serious local or systemic reactions were observed among the study participants. Two doses of vaccine containing 7–20 µg of the A/USSR/77 (H1N1) viral antigen were required to achieve serum titers of hemagglutinin-inhibiting (HAI) antibody >1:40. However, single doses containing 7–20 µg of the A/Texas/77 (H3N2) or B/Hong Kong/72 antigens stimulated serum HAI antibody levels of 1:40.Keywords
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