CHEMOTHERAPEUTIC STUDIES ON LITOMOSOIDES-CARINII INFECTION OF MASTOMYS-NATALENSIS .8. ACTION OF FURAZOLIDONE ON ADULT WORMS AND MICROFILARIAE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 30  (3) , 376-382
Abstract
After oral administration of furazolidone in doses of 5 .times. 50 mg/kg and 1 .times. 100 mg/kg body weight to L. carinii-infected M. natalensis microfilaremia decreased continuously and was reduced by more than 98% 42 days after start of treatment. After the 5-day treatment all adult female and male worms were found dead and encapsulated within 2 wk, whereas after the single dose 100% of the female parasites were encapsulated 28 days after treatment. In untreated animals quantitative examinations of the intrauterine stages showed an average number of 500 .times. 103 embryos/adult female worm. Following the 5-day treatment the number of embryos/female parasite was reduced after 42 days to 12.5 .times. 103, and after the single treatment to 26.9 .times. 103. By classification into 5 different stages (2- and 4-cell stages, Morula stage, "Horse-shoe" stage, "Ring" and "Brezel" stages, and intrauterine microfilariae) an embryogram showed a continuous increase in pathologically-altered embryos during the whole observation period. The 2- and 4-cell stages suffered the most damage. By 16 days after the end of the 5-day treatment and by 28 days after the single treatment all embryonic stages in the uteri were pathologically altered. Furazolidone possesses high macrofilaricidal activity together with a considerable adverse effect on embryogenesis and some delayed effect on microfilaremia.

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