The chemistry of pyrazine and its derivatives. X. The mono‐ and diacylation of tetramethylpyrazine
- 1 October 1964
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 1 (4) , 196-200
- https://doi.org/10.1002/jhet.5570010410
Abstract
By the use of sodium amide in liquid ammonia or phenyllithium in ether as the condensing agent it has been possible to synthesize a series of ketones containing the pyrazine ring with the structure, RCOCH2C4N2(CH3)3 where R is alkyl, aryl or heterocyclic. Also, under appropriate conditions, tetramethylpyrazine has been diacylated to give three diketones of the type (2‐RCOCH2)‐(6‐R' COCH2)C4N2(CH3)2‐3, 5.Keywords
This publication has 8 references indexed in Scilit:
- The Chemistry of Pyrazine and Its Derivatives. VIII. Diketones Derived from the Monoacylation of 2-Methyl-6-(acylmethyl)pyrazines and the Diacylation of 2,6-Dimethylpyrazine1The Journal of Organic Chemistry, 1964
- The Chemistry of Pyrazine and Its Derivatives. VII. The Synthesis of Vinylpyrazine and Substituted Vinylpyrazines1The Journal of Organic Chemistry, 1962
- The Chemistry of Pyrazine and Its Derivatives. VI. The Synthesis of Carbinols Containing the Pyrazine Nucleus1The Journal of Organic Chemistry, 1962
- Chemistry of Pyrazine and Its Derivatives. V. Acylation and Alkylation of 2,6-Dimethylpyrazine and Certain Other Pyrazine Derivatives1The Journal of Organic Chemistry, 1962
- The Chemistry of Pyrazine and Its Derivatives. IV. The Alkylation and Arylation of Methylpyrazine1The Journal of Organic Chemistry, 1961
- Chemistry of Pyrazine and Its Derivatives. III. The Synthesis of Carbinols by the Participation of Methylpyrazine in Aldol-type Condensations1Journal of the American Chemical Society, 1959
- The Chemistry of Pyrazine and its Derivatives. II. The Acylation of Methylpyrazine1Journal of the American Chemical Society, 1959
- Chemistry of Pyrazine and its Derivatives. I. The Hypohalite Oxidation of Acetonyl- and Phenacylpyrazine1The Journal of Organic Chemistry, 1958