Mitochondrial Dysfunction Is a Common Phenotype in Aging and Cancer
- 1 June 2004
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1019 (1) , 260-264
- https://doi.org/10.1196/annals.1297.043
Abstract
An interesting clue with regard to molecular mechanisms underlying age-associated cancers is the apparent defect in mitochondrial function. Recent studies demonstrate a progressive decline in mitochondrial function during aging. Studies have established that the decline in mitochondrial function is due to the accumulation of mutations in mitochondrial DNA. These observations suggest that the mitochondrial dysfunction that accompanies aging may exert a major influence on carcinogenesis.Keywords
This publication has 15 references indexed in Scilit:
- Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiaeNucleic Acids Research, 2003
- Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breastOncogene, 2003
- Mitochondrial DNA polymorphisms associated with longevity in a Finnish populationHuman Genetics, 2003
- A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevityNature Genetics, 2002
- Mitochondrial genotypes and cytochrome b variants associated with longevity or Parkinson's diseaseZeitschrift für Neurologie, 2002
- Mitochondrial DNA determines the cellular response to cancer therapeutic agentsOncogene, 1999
- Mitochondrial DNA Mutations in AgingPublished by Springer Nature ,1998
- Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stressProceedings of the National Academy of Sciences, 1997
- Repair of products of oxidative DNA base damage in human cellsNucleic Acids Research, 1996
- Do mitochondrial DNA fragments promote cancer and aging?FEBS Letters, 1988