ISOLATION, PURIFICATION, AND CHARACTERIZATION OF ANTICAPSIN1)

1 January 1970

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 23 (12) , 613-617
https://doi.org/10.7164/antibiotics.23.613

Abstract

Anticapsin is a new biologically active metabolite isolated from the culture filtrate of a strain of Streptomyces griseoplanus. The metabolite inhibits the formation of the hyaluronic acid capsules of Streptococcus pyogenes at a minimal concentration of 3 mcg/ml. Anticapsin (C₉H₁₃O₄N), an amino acid (pKa=4.3; 10.1 in 66% DMF), is chemically related to bacilysin.

Keywords

ANTICAPSIN1
PURIFICATION
GRISEOPLANUS
BACILYSIN
STREPTOMYCES
AMINO
HYALURONIC
CAPSULES
MINIMAL

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