Introduction to the Pharmacology of Suprofen

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Abstract
A number of peripherally acting analgesics have become available in the past 2 decades for the treatment of mild to moderate pain of diverse etiology. The action of these agents is based on their putative ability to inhibit prostaglandin [PG] biosynthesis and attenuate hyperalgesia. Suprofen is a new and potent peripherally acting analgesic with antiinflammatory and antipyretic properties which appears to inhibit PG synthetase in a tissue-selective manner. In preclinical studies in rats suprofen possessed a wide separation of analgesic activity from gastrointestinal irritation. Suprofen appears to exert its pharmacological effect by inhibiting PG synthesis from precursor arachidonic acid, inhibiting the pain induced by bradykinin and by raising the threshold to pain induced by PG. The onset of action is rapid with peak analgesic effect reached in 1-2 h. Suprofen may be an extremely valuable and versatile analgesic for the clinical management of pain.