The small nuclear GTPase Ran: How much does it run?
- 5 February 1996
- Vol. 18 (2) , 103-112
- https://doi.org/10.1002/bies.950180206
Abstract
Ran is one of the most abundant and best conserved of the small GTP binding and hydrolyzing proteins of eukaryotes. It is located predominantly in cell nuclei. Ran is a member of the Ras family of GTPases, which includes the Ras and Ras‐like proteins that regulate cell growth and division, the Rho and Rac proteins that regulate cytoskeletal organization and the Rab proteins that regulate vesicular sorting. Ran differs most obviously from other members of the Ras family in both its nuclear localization, and its lack of sites required for post‐translational lipid modification. Ran is, however, similar to other Ras family members in requiring a specific guanine nucleotide exchange factor (GEF) and a specific GTPase activating protein (GAP) as stimulators of overall GTPase activity. In this review, the multiple cellular functions of Ran are evaluated with respect to its known biochemistry and molecular interactions.Keywords
This publication has 79 references indexed in Scilit:
- A Ran-binding motif in nuclear pore proteinsTrends in Cell Biology, 1995
- Diverse Effects of the Guanine Nucleotide Exchange Factor RCC1 on RNA TransportScience, 1995
- Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1Biochemistry, 1995
- Isolation of human NuMA proteinFEBS Letters, 1994
- Phenotype of the fission yeast cell cycle regulatory mutant pim1‐46 is suppressed by a tobacco cDNA encoding a small, Ran‐like GTP‐binding proteinThe Plant Journal, 1994
- Cloning and Expression of a cDNA-Encoding the Homologue of Ran/TC4 GTP-Binding Protein from Plasmodium falciparumBiochemical and Biophysical Research Communications, 1994
- NuMA is required for the proper completion of mitosis.The Journal of cell biology, 1993
- Molecular cloning of a novel ras‐like protein from chickenFEBS Letters, 1992
- Characterization of the opposite-strand genes from the mouse bidirectionally transcribed HTF9 locusGene, 1991
- Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.Genes & Development, 1987