Drug Interaction between Rifampicin and Cotrimoxazole in Patients with Tuberculosis
- 1 November 1991
- journal article
- research article
- Published by SAGE Publications in Human & Experimental Toxicology
- Vol. 10 (6) , 419-421
- https://doi.org/10.1177/096032719101000609
Abstract
1 Patients ( n = 15) who were admitted with complications of tuberculosis, were given antitubercular therapy (ATT) with rifampicin (RIF), for a minumum period of 15 d, and cotrimoxazole (CTZ), concurrently, for 5-10 d. 2 The serum RIF levels were measured before the start of CTZ treatment and at the end of its administration. 3 The plasma half-life (t½) of RIF increased significantly from 1.92 ± 0.57 h to 2.31 ± 0.134 h after CTZ treatment. 4 The mean serum levels of RIF increased significantly at 4 and 6 h after CTZ administration.Keywords
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