PRODUCTION OF CATTLE IMMUNOTOLERANT TO BOVINE VIRAL DIARRHEA VIRUS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 48  (2) , 156-161
Abstract
Inoculation of bovine virus diarrhea virus into 58-125 day old fetuses of bovine virus diarrhea virus seropositive pregnant cows, or inoculation of bovine virus diarrhea virus into seronegative cows 42-114 days pregnant, may produce clinically normal calves which are persistently infected with the specific isolate of bovine virus diarrhea virus yet seronegative to the homologous and heterologous isolates. Reinoculation of these persistently infected cattle with their homologus isolate produced no neutralizing antibody response to bovine virus diarrhea virus. These persistently infected cattle were immunocompetent as they developed neutralizing serotiters to infectious bovine rhinotracheitis, parainfluenza-type 3 viruses and agglutinating serotiters to Pasteurella haemolytica.