Aerosol Steroids as Primary Treatment of Mild Asthma
- 8 August 1991
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 325 (6) , 425-426
- https://doi.org/10.1056/nejm199108083250610
Abstract
These are revolutionary times for patients with asthma. The disease is no longer considered the consequence of just bronchospasm or hyperactive airways. Rather, even in its mildest form asthma is considered an inflammatory disease, often described as "chronic desquamating eosinophilic bronchitis."1 , 2 The respiratory epithelium appears to bear the brunt of the inflammatory attack; it is vacuolated, and ciliated cells are shed into the bronchial lumen. Eosinophils not only become more numerous in the blood, the bronchial mucosa, and the sputum, but also damage the epithelium.3 Studies using bronchoalveolar lavage and endobronchial biopsy combined with the techniques of cellular and molecular . . .Keywords
This publication has 8 references indexed in Scilit:
- Comparison of a β2-Agonist, Terbutaline, with an Inhaled Corticosteroid, Budesonide, in Newly Detected AsthmaNew England Journal of Medicine, 1991
- Eosinophilic Inflammation in AsthmaNew England Journal of Medicine, 1990
- The assessment and treatment of asthma: A conference reportJournal of Allergy and Clinical Immunology, 1990
- Cellular Events in the Bronchi in Mild Asthma and after Bronchial ProvocationAmerican Review of Respiratory Disease, 1989
- A Longitudinal Study of the Occurrence of Bronchial Hyperresponsiveness in Western Red Cedar WorkersAmerican Review of Respiratory Disease, 1988
- New therapeutic approaches in asthmaJournal of Allergy and Clinical Immunology, 1986
- Candidiasis and dysphonia complicating beclomethasone treatment of asthmaJournal of Allergy and Clinical Immunology, 1980
- THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSAJournal of Clinical Pathology, 1960