Protective Activities of Aucubin Against Carbon Tetrachloride-Induced Liver Damage in Mice

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Abstract
An iridoid glucoside, aucubin was isolated from Aucuba japonica leaves and its protective activities against CC14,-induced hepatotoxicity were evaluated by measuring the duration of hypnosis induced by hexobarbital after CCl4 challenge (0.2 ml/kg/day, po) and the levels of serum glutamic-oxalacetic (GOT) and serum glutamic-pyruvic transaminase (GPT). The duration of hypnosis for the saline control group, the CCI4 alone treated group and the aucubin plus CCI4 treated group was 24.8 ± 8.5, 60.5 ± 9.5 and 28.0 ± 3.2 min, respectively. Treatment of mice with aucubin also effectively protected against CCl4-induced increased serum GOT and GPT activities. It was found that aucubin inhibited hepatic RNA and protein syntheses in vivo. Such inhibitory effects of aucubin might be responsible for protective activities against CCI4-induced liver damage.