DETERMINATION OF VARIOUS CYTOKINES AND TYPE III PROCOLLAGEN AMINOPEPTIDE LEVELS IN BRONCHOALVEOLARAVAGE FLUID OF THE PATIENTS WITH PULMONARY FIBROSIS: INVERSE CORRELATION BETWEEN TYPE III PROCOLLAGEN AMINOPEPTIDE AND INTERFERON-γ IN PROGRESSIVE PATIENTS

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Abstract
We measured levels of cytokines and type III procollagen aminopeptides (procollagen III peptides) in bronchoaJveolar lavagc fluid obtained from 20 patients with stable pulmonary fibrosis (PF) and seven patients with progressive PF, and nine control subjects to determine the role of cytokines in the development of PF. Procollagen III peptide levels were markedly increased in progressive PF patients. Tumour necrosis factor-α, interleukin-6, transforming growth factor-β} and interferon-γ (IFN-γ) levels were elevated in both PF patients as compared with controls, with a tendency of higher levels in progressive patients, whereas interleuldn-1β (IL-1β) level was decreased in both PF patients. When the correlation between procollagen III peptide and various cytokine levels was analysed the only significant correlation was inversely between procollagen HI peptide and IFN-y in progressive PF patients. These results indicated that although multiple cytokines may be involved in the development of PF, the negative role of IFN-γ in active collagen synthesis could be also important.

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